Unusual presentation of Precursor B Lymphoblastic Lymphoma originating from the stomach: One more case and review of the literature

Abstract

Precursor B lymphoblastic lymphoma (PBL) is an aggressive neoplasm of precursor lymphocytes of B-cell lineage. Extranodal sites are often affected, however gastrointestinal involvement is rarely encountered. We report a case of PBL diagnosed in gastric biopsy of a 72-year-old female. Endoscopy showed multiple polypoid lesions in the stomach. Histologically, the tumor cells exhibited blastic morphology and immunohistochemical expression of terminal deoxynucleotidyl transferase (TdT), CD79a, CD20, CD10 and PAX-5, whereas they were CD34, MPO, and CD3 negative. The diagnosis of this rare entity in unusual extranodal sites such as the stomach is challenging, and it is based on detailed histopathological and immunohistochemical analysis combined to clinical correlations.