Diffuse lipoatrophic panniculitis: A disfiguring disease

Abstract

Lipoatrophic panniculitis is a rare disease in which atrophy of the subcutaneous fat is the main residual lesion. We report the case of a 49-year-old woman without evidence of any associated connective tissue diseases, with a four months history of repeated painful and erythematous nodules and plaques of lower limbs that resolved leaving depressed areas of the skin. Cutaneous biopsy showed lymphohistiocytic lobular panniculitis. Our patient responded well to a combination of prednisone and hydroxychloroquine.