Rare case of non-Hodgkin’s lymphoma in a patient with multiple hyperplastic colon polyps

Abstract

Colon polyposis, such as familial adenomatous polyposis, Puetz-Jegher’s Syndrome, mutY homolog-associated polyposis, and hyperplastic/serrated polyposis syndrome, have been linked to several different types of cancer, including cancers of the gastrointestinal tract, thyroid, liver, central nervous system, genital tract, breast, pancreas, bone, sebaceous glands, ovaries, bladder, and skin. However, to date there have been no reports of an association between any of the aforementioned types of colon polyposis and lymphoma. Here, we report the case of a 79-year-old man with multiple hyperplastic polyps in the colon who was diagnosed with diffuse large B cell lymphoma of the pelvic bone. Future reporting of such associations and follow-up genetic testing is necessary to determine if there is a familial association and whether steps are needed to prevent occurrence by screening.