Advanced membrano - proliferative glomerulonephritis in a 2-month-old Nigerian male infant: A case report

Abstract

Introduction: Membrano-proliferative glomerulonephritis (MPGN) is rare in infancy and remains an uncommon cause of chronic nephritis which primarily affects children and young adults.

Case presentation: The index case is a 2-month-old male infant who presented with vomiting, generalized body swelling and anuria following ingestion of some parent-prescribed drugs. Following mortality on the 28th day of admission, a post-mortem evaluation revealed an advanced MPGN: a histological picture best described as “a 2-month-old with the kidneys of a 70-year-old”.

Conclusion: The case report aims to underscore the possibility of MPGN in early infancy albeit rare. It also highlights the need for a high index of suspicion in cases of unexplained acute renal failure especially in settings where there are limited facilities for diagnosis.