The study of myocardial protective effect of creatine phosphate sodium in liver transplant patients

Abstract

Objective: To study the cardioprotective effectof creatine phosphate sodium by measuring perioperative myocardial enzymes of allogeneic liver transplant patients.

Methods: The 26 cases of orthotopic liver transplant patients were randomly divided into control group and creatine phosphate sodium group, 13 cases in each group. The creatine phosphate sodium group were given creatine phosphate sodium 30 mg/kg at the time of induction. The control group were given equal amount of N.S. All patients at six-phase of before surgery, after anesthesia,before anhepatic phase, anhepatic phase,new liver and the 12 hours after surgery extraction radial artery. The CK, CK-MB and cTnI activity was measured.

Results: To compared with control group, creatine phosphate sodium group’s plasma CK, CK-MB and cTnI concentrations in before anhepatic phase, anhepatic phase, new liver and the 12 hours after surgery 4 phase are significantly lower ( p<0.05). 

Conclusions: The creatine phosphate sodium has a protective effect on liver transplantation in patients with myocardial damage.