Expressions of apoptosis inducing factor and heat-shock protein 70 in gastric polypss and gastric cancer and their correlation with gastric cancer

Abstract

Objective: To explore the effects of apoptosis inducing factor (AIF) and heat-shock protein 70 (HSP70) in the occurrence and development of gastric cancer by detecting their mRNA levels in gastric polypss and gastric cancer, and provide a new way and insight for the early diagnosis and treatment of gastric cancer.

Methods: Gastric biopsy samples of 120 patients in the Third Hospital of Inner Mongolia Medical University were collected. According to their pathological characteristics, the samples were divided into four groups as followed: normal gastric mucosa group (n = 30), gastric hyperplastic polypss group (n = 30), gastric adenomatous polypss group (n = 30) and gastric cancer group (n = 30). The expressions of AIF and HSP70 mRNA were detected by real-time PCR.

Results: The expressions of AIF and HSP70 mRNA were gradually increased in gastric hyperplastic polypss, gastril adenomatous polypss and gastric cancer, the difference was significant (p < .05). In the tissues of adenomatous polypss and gastric cancer, the expression of AIF mRNA was positively correlated with HSP70 mRNA (p < .01).

Conclusions: AIF and HSP70 are correlated with the development of gastric cancer. AIF and HSP70 may act synergistically in the development of gastric cancer. Both of them can be used as markers for the diagnosis of gastric cancer.