Effect observation of exfoliative cytology combined with CEA, CA125, CA15-3 and CA19-9 examinations in the diagnosis of malignant serous effusion

Abstract

Objective: To study the effect of exfoliative cytology combined with CEA, CA125, CA15-3 and CA19-9 examinations on the diagnosis of malignant serous effusion.

Methods: 236 cases of patients who were diagnosed as serous effusion during inpatient in our hospital from January of 2015 to January of 2017 were selected as research objects. According to biopsy and pathological examinations, the diagnostic results were cleared that there were 136 cases of patients with benign serous effusion (benign group) and 100 cases of patients with malignant serous effusion (malignant group). Two groups of patients were both given exfoliative cytology combined with CEA, CA125, CA15-3 and CA19-9 examinations for tumor markers to analyze the effect of exfoliative cytology combined with CEA, CA125, CA15-3 and CA19-9 examinations on the diagnosis of malignant serous effusion.

Results: The levels of tumor markers CEA, CA125, CA15-3 and CA19-9 in the benign group were all lower than those in the malignant group, and the difference was of statistical significance (p < .05). In addition, exfoliative cytology combined with CEA, CA125, CA15-3 and CA19-9 examinations showed a higher sensitivity, specificity and accuracy than any of the above examinations alone, and the difference was of statistical significance (p < .05).

Conclusions: Exfoliative cytology combined with CEA, CA125, CA15-3 and CA19-9 examinations can effectively improve the diagnostic accuracy of malignant serous effusion and is worthy of being spread clinically.