Evaluation of materno-fetal antibody transfer in patients with antiphospholipid syndrome

Abstract

Introduction: Antiphospholipid syndrome (APS) is characterized by thrombotic events and recurrent pregnancy losses and is considered the most common acquired thrombophilia.

Objective: To carry out a narrative review of the transplacental passage and antibodies in patients with APS.

Methods: A narrative literature review.

Results: When it is not associated with any connective tissue disease, it is said to be primary, and when in association with systemic lupus erythematosus, it is said to be secondary. Gestational morbidity is frequent, and it is crucial to evaluate the passage of these antibodies transplacentally since there are animal models of the syndrome with passive transfer of these antibodies. The transplacental passage of specific antibodies has already been determined in studies, which demonstrated low levels of these antibodies in the maternal serum, but an efficient transplacental passage for the newborn.

Conclusions: There are few studies on this maternal-infant passage in patients with APS reviewed here.