Experimental study on the protective effect of propofol on liver injury in rats with sepsis

Lidong Su, Rigen Mo, Bo Feng

Abstract


Objective: To observe the protective effect of propofol on liver injury in rats with sepsis and explore its protective mechanism. 

Methods: 24 Wister rats were randomly divided into 3 groups, with 8 rats in each group: the sham operation group, the saline group and the propofol group. An intraperitoneal injection of LPS 8 mg/kg was used in the saline group, with continuous infusion of normal saline. An intraperitoneal injection of LPS 8 mg/kg and continuous infusion of propofol saline solution were also performed in the propofol group.

Results: Compared with the saline group, the levels of ALT, AST, IL-6 and TNF-α in the sham operation group and the propofol group were significantly lower than those in the saline group. 

Conclusions: Propofol has a certain protective effect on liver injury in rats with sepsis.


Full Text:

PDF


DOI: https://doi.org/10.5430/dcc.v3n1p1

Refbacks

  • There are currently no refbacks.


Discussion of Clinical Cases  ISSN 2375-8449(Print)  ISSN 2375-8473(Online)

Copyright © Sciedu Press 

To make sure that you can receive messages from us, please add the 'sciedu.ca' and ‘sciedupress.com’ domains to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', please check your 'spam' or 'junk' folder.