Two cases of insulin autoimmune syndrome induced by exogenous insulin in diabetic patients

Abstract

Objective: To improve the recognition of clinicians on insulin autoimmune syndrome (IAS) induced by exogenous insulin.

Methods: Two cases of IAS induced by exogenous insulin were retrospectively analyzed.

Results: Two patients had hypoglycemia occurred during the night. They had dissociation between C-peptide and insulin, accompanied by high titer of insulin autoantibody (IAA). Hypoglycemia episodes were ameliorated after the use of oral hypoglycemic agents.

Conclusions: Due to the role of insulin to be covered up, diabetes patients after the application of exogenous insulin induced IAS are easily misdiagnosed, high titer IAA and insulin and C-peptide separation phenomenon have been confirmed with diagnostic value.