Relationship of plasma homocysteine, soluble intercellular adhesion molecule-1, high mobility group box 1 protein with carotid intima-media thickness in elderly patients with type 2 diabetes mellitus

Abstract

Objective: To explore the relationship of plasma homocysteine (Hcy), soluble intercellular adhesion molecule-1 (sICAM-1) and high mobility group box 1 protein (HMGB1) with carotid intima-media thickness (c-IMT) in elderly patients with type 2 diabetes mellitus.

Methods: A total of 100 elderly patients who were diagnosed as type 2 diabetes mellitus in Baogang Hospital of Inner Mongolia from June 2017 to May 2020 were chosen as research objects. According to c-IMT, they were divided into the normal group (n = 35), the mild to moderate group (n = 41) and the severe group (n = 24). The expression levels of plasma Hcy, sICAM-1 and HMGB1 were compared between groups respectively. Pearson’s correlation coefficient was used to analyze the relationship of plasma Hcy, sICAM-1, HMGB1 with c-IMT.

Results: The comparison in plasma Hcy, sICAM-1, HMGB1 and c-IMT among the three groups of patients was of statistical significance (p < .05). The results of correlation analysis showed that the expression levels of plasma Hcy, sICAM-1 and HMGB1 were positively correlated with c-IMT in elderly patients with type 2 diabetes mellitus (r = .627, .598, .614; p < .05).

Conclusions: The expression levels of plasma Hcy, sICAM-1 and HMGB1 are abnormally increased in elderly patients with type 2 diabetes mellitus, and related to c-IMT, which can provide a strong evidence for clinical diagnosis and treatment by detecting their levels in clinical practice.